Designed by Mark Cavagnero Associates, this property spans an impressive 281,800 square feet and six-stories high, housing wet and dry research and clinical labs, as well as a vertical vivarium. The facility was conceived as a series of interlocked volumes with a four-story research block lifted above a transparent two-story clinical volume.

The UCSF Weill Neuroscience Building goal is to connect and integrate historically separated disciplines. Among its priorities is the integration of psychiatry research from the Oberndorf Research Labs into the neuroscience program. Their goal is to accelerate understanding the brain and develop novel treatments from psychiatric disorders such as autism, depression, and schizophrenia, alongside advancements in neurology.